Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis (2024)

Wormser, D., Di Angelantonio, E., Kaptoge, S., Wood, A. M., Gao, P., Sun, Q., Walldius, G., Selmer, R., Verschuren, W. M. M., Bueno-de-Mesquita, H. B., Engstrom, G., Ridker, P. M., Njolstad, I., Iso, H., Holme, I., Giampaoli, S., Tunstall-Pedoe, H., Gaziano, J. M., Brunner, E., ... Butterworth, A. S. (2012). Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis. International Journal of Epidemiology, 41(5), 1419-1433. https://doi.org/10.1093/ije/dys086

Wormser, D. ; Di Angelantonio, E. ; Kaptoge, S. et al. / Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis. In: International Journal of Epidemiology. 2012 ; Vol. 41, No. 5. pp. 1419-1433.

@article{1cd1f7ef91534514950db93ebd7ba936,

title = "Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis",

abstract = "Background: The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain. Methods: We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in 121 prospective studies. Results: For people born between 1900 and 1960, mean adult height increased 0.5-1 cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5 cm greater height were 0.97 (95% confidence interval: 0.96-0.99) for death from any cause, 0.94 (0.93-0.96) for death from vascular causes, 1.04 (1.03-1.06) for death from cancer and 0.92 (0.90-0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. In contrast, height was positively associated with death from ruptured aortic aneurysm, pulmonary embolism, melanoma and cancers of the pancreas, endocrine and nervous systems, ovary, breast, prostate, colorectum, blood and lung. HRs per 6.5 cm greater height ranged from 1.26 (1.12-1.42) for risk of melanoma death to 0.84 (0.80-0.89) for risk of death from chronic obstructive pulmonary disease. HRs were not appreciably altered after further adjustment for adiposity, blood pressure, lipids, inflammation biomarkers, diabetes mellitus, alcohol consumption or socio-economic indicators. Conclusion: Adult height has directionally opposing relationships with risk of death from several different major causes of chronic diseases. Published by Oxford University Press on behalf of the International Epidemiological Association {\textcopyright} The Author 2012; all rights reserved.",

author = "D. Wormser and {Di Angelantonio}, E. and S. Kaptoge and A.M. Wood and P. Gao and Q. Sun and G. Walldius and R. Selmer and W.M.M. Verschuren and H.B. Bueno-de-Mesquita and G. Engstrom and P.M. Ridker and I. Njolstad and H. Iso and I. Holme and S. Giampaoli and H. Tunstall-Pedoe and J.M. Gaziano and E. Brunner and F Kee and A. Tosetto and C. Meisinger and H. Brenner and P. Ducimetiere and P.H. Whincup and R.W. Tipping and I. Ford and P. Cremer and A. Hofman and L. Wilhelmsen and R. Clarke and {de Boer}, I.H. and J.W. Jukema and A.M. Ibanez and D.A. Lawlor and R.B. D'Agostino and B. Rodriguez and E. Casiglia and C.D.A. Stehouwer and L.A. Simons and P.J. Nietert and E. Barrett-Connor and D.B. Panagiotakos and C. Bjorkelund and T.E. Strandberg and S. Wassertheil-Smoller and D.G. Blazer and T.W. Meade and L. Welin and K. Svardsudd and M. Woodward and A. Nissinen and D. Kromhout and T. Jorgensen and R.S. Tilvis and J.M. Guralnik and A. Rosengren and J.O. Taylor and S. Kiechl and G.R. Dagenais and F.G.R. Fowkes and R.B. Wallace and K.T. Khaw and J.A. Shaffer and M. Visser and J. Kauhanen and J.T. Salonen and J. Gallacher and Y. Ben-Shlomo and A. Kitamura and J. Sundstrom and P. Wennberg and Y. Kiyohara and M. Daimon and {de la Camara}, A.G. and J.A. Cooper and A. Onat and R. Devereux and K.J. Mukamal and R. Dankner and M.W. Knuiman and C.J. Crespo and R.T. Gansevoort and U. Goldbourt and B.G. Nordestgaard and J.E. Shaw and M. Mussolino and H. Nakagawa and A. Fletcher and L.H. Kuller and R.F. Gillum and V. Gudnason and G. Assmann and N. Wald and P.R. Jousilahti and P. Greenland and M. Trevisan and H. Ulmer and A.S. Butterworth",

year = "2012",

doi = "10.1093/ije/dys086",

language = "English",

volume = "41",

pages = "1419--1433",

journal = "International Journal of Epidemiology",

issn = "0300-5771",

publisher = "Oxford University Press",

number = "5",

}

Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis. / Wormser, D.; Di Angelantonio, E.; Kaptoge, S. et al.
In: International Journal of Epidemiology, Vol. 41, No. 5, 2012, p. 1419-1433.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis

AU - Wormser, D.

AU - Di Angelantonio, E.

AU - Kaptoge, S.

AU - Wood, A.M.

AU - Gao, P.

AU - Sun, Q.

AU - Walldius, G.

AU - Selmer, R.

AU - Verschuren, W.M.M.

AU - Bueno-de-Mesquita, H.B.

AU - Engstrom, G.

AU - Ridker, P.M.

AU - Njolstad, I.

AU - Iso, H.

AU - Holme, I.

AU - Giampaoli, S.

AU - Tunstall-Pedoe, H.

AU - Gaziano, J.M.

AU - Brunner, E.

AU - Kee, F

AU - Tosetto, A.

AU - Meisinger, C.

AU - Brenner, H.

AU - Ducimetiere, P.

AU - Whincup, P.H.

AU - Tipping, R.W.

AU - Ford, I.

AU - Cremer, P.

AU - Hofman, A.

AU - Wilhelmsen, L.

AU - Clarke, R.

AU - de Boer, I.H.

AU - Jukema, J.W.

AU - Ibanez, A.M.

AU - Lawlor, D.A.

AU - D'Agostino, R.B.

AU - Rodriguez, B.

AU - Casiglia, E.

AU - Stehouwer, C.D.A.

AU - Simons, L.A.

AU - Nietert, P.J.

AU - Barrett-Connor, E.

AU - Panagiotakos, D.B.

AU - Bjorkelund, C.

AU - Strandberg, T.E.

AU - Wassertheil-Smoller, S.

AU - Blazer, D.G.

AU - Meade, T.W.

AU - Welin, L.

AU - Svardsudd, K.

AU - Woodward, M.

AU - Nissinen, A.

AU - Kromhout, D.

AU - Jorgensen, T.

AU - Tilvis, R.S.

AU - Guralnik, J.M.

AU - Rosengren, A.

AU - Taylor, J.O.

AU - Kiechl, S.

AU - Dagenais, G.R.

AU - Fowkes, F.G.R.

AU - Wallace, R.B.

AU - Khaw, K.T.

AU - Shaffer, J.A.

AU - Visser, M.

AU - Kauhanen, J.

AU - Salonen, J.T.

AU - Gallacher, J.

AU - Ben-Shlomo, Y.

AU - Kitamura, A.

AU - Sundstrom, J.

AU - Wennberg, P.

AU - Kiyohara, Y.

AU - Daimon, M.

AU - de la Camara, A.G.

AU - Cooper, J.A.

AU - Onat, A.

AU - Devereux, R.

AU - Mukamal, K.J.

AU - Dankner, R.

AU - Knuiman, M.W.

AU - Crespo, C.J.

AU - Gansevoort, R.T.

AU - Goldbourt, U.

AU - Nordestgaard, B.G.

AU - Shaw, J.E.

AU - Mussolino, M.

AU - Nakagawa, H.

AU - Fletcher, A.

AU - Kuller, L.H.

AU - Gillum, R.F.

AU - Gudnason, V.

AU - Assmann, G.

AU - Wald, N.

AU - Jousilahti, P.R.

AU - Greenland, P.

AU - Trevisan, M.

AU - Ulmer, H.

AU - Butterworth, A.S.

PY - 2012

Y1 - 2012

N2 - Background: The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain. Methods: We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in 121 prospective studies. Results: For people born between 1900 and 1960, mean adult height increased 0.5-1 cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5 cm greater height were 0.97 (95% confidence interval: 0.96-0.99) for death from any cause, 0.94 (0.93-0.96) for death from vascular causes, 1.04 (1.03-1.06) for death from cancer and 0.92 (0.90-0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. In contrast, height was positively associated with death from ruptured aortic aneurysm, pulmonary embolism, melanoma and cancers of the pancreas, endocrine and nervous systems, ovary, breast, prostate, colorectum, blood and lung. HRs per 6.5 cm greater height ranged from 1.26 (1.12-1.42) for risk of melanoma death to 0.84 (0.80-0.89) for risk of death from chronic obstructive pulmonary disease. HRs were not appreciably altered after further adjustment for adiposity, blood pressure, lipids, inflammation biomarkers, diabetes mellitus, alcohol consumption or socio-economic indicators. Conclusion: Adult height has directionally opposing relationships with risk of death from several different major causes of chronic diseases. Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2012; all rights reserved.

AB - Background: The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain. Methods: We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in 121 prospective studies. Results: For people born between 1900 and 1960, mean adult height increased 0.5-1 cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5 cm greater height were 0.97 (95% confidence interval: 0.96-0.99) for death from any cause, 0.94 (0.93-0.96) for death from vascular causes, 1.04 (1.03-1.06) for death from cancer and 0.92 (0.90-0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. In contrast, height was positively associated with death from ruptured aortic aneurysm, pulmonary embolism, melanoma and cancers of the pancreas, endocrine and nervous systems, ovary, breast, prostate, colorectum, blood and lung. HRs per 6.5 cm greater height ranged from 1.26 (1.12-1.42) for risk of melanoma death to 0.84 (0.80-0.89) for risk of death from chronic obstructive pulmonary disease. HRs were not appreciably altered after further adjustment for adiposity, blood pressure, lipids, inflammation biomarkers, diabetes mellitus, alcohol consumption or socio-economic indicators. Conclusion: Adult height has directionally opposing relationships with risk of death from several different major causes of chronic diseases. Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2012; all rights reserved.

U2 - 10.1093/ije/dys086

DO - 10.1093/ije/dys086

M3 - Article

SN - 0300-5771

VL - 41

SP - 1419

EP - 1433

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

IS - 5

ER -

Wormser D, Di Angelantonio E, Kaptoge S, Wood AM, Gao P, Sun Q et al. Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis. International Journal of Epidemiology. 2012;41(5):1419-1433. doi: 10.1093/ije/dys086